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A combined 1 H perfusion/ 3 He ventilation NMR study in rat lungs
Author(s) -
Crémillieux Y.,
Berthezène Y.,
Humblot H.,
Viallon M.,
Canet E.,
Bourgeois M.,
Albert T.,
Heil W.,
Briguet A.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199904)41:4<645::aid-mrm1>3.0.co;2-v
Subject(s) - ventilation (architecture) , perfusion , lung , medicine , pulmonary embolism , perfusion scanning , magnetic resonance imaging , ventilation perfusion mismatch , nuclear medicine , radiology , cardiology , physics , thermodynamics
Abstract The assessment of both pulmonary perfusion and ventilation is of crucial importance for a proper diagnosis of some lung diseases such as pulmonary embolism. In this study, we demonstrate the feasibility of combined magnetic resonance imaging lung ventilation and perfusion performed serially in rat lungs. Lung ventilation function was assessed using hyperpolarized 3 He, and lung perfusion proton imaging was demonstrated using contrast agent injection. Both imaging techniques have been implemented using projection‐reconstruction sequences with free induction decay signal acquisitions. The study focused on fast three‐dimensional (3D) data acquisition. The projection‐reconstruction sequences used in this study allowed 3D data set acquisition in several minutes without high‐performance gradients. 3D proton perfusion/helium ventilation imaging has been demonstrated on an experimental rat model of pulmonary embolism showing normal lung ventilation associated with lung perfusion defect. Assuming the possibility, still under investigation, of showing lung obstruction pathologies using 3 He imaging, these combined perfusion/ventilation methods could play a significant clinical role in the future for diagnosis of several pulmonary diseases. Magn Reson Med 41:645–648, 1999. © 1999 Wiley‐Liss, Inc.