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Catalytic Concepts for the Enantioselective Synthesis of α ‐Amino and α ‐Hydroxy Phosphonates
Author(s) -
Gröger Harald,
Hammer Benedikt
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(20000317)6:6<943::aid-chem943>3.0.co;2-4
Subject(s) - enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , organic chemistry , stereochemistry
Abstract The enantioselective synthesis of α ‐amino‐ and α ‐hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed to date. The described synthetic routes are based on different catalytic concepts, namely, hydrogenation, reductions, dihydroxylation, aminohydroxylation, and hydrophosphonylation.