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A new 99m Tc labeled porphyrin for specific imaging of Sarcoma 120: Synthesis and biological study in a Swiss mouse model
Author(s) -
Shetty S .J.,
Murugesan S.,
Chatterjee S. R.,
Banerjee S.,
Srivastava T. S.,
Noronha O. P. D.,
Samuel A. M.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199605)38:5<411::aid-jlcr858>3.0.co;2-w
Subject(s) - porphyrin , chemistry , sarcoma , combinatorial chemistry , cancer research , biochemistry , pathology , medicine
Abstract A new porphyrin meso ‐5,10,15,20‐tetrakis [3,4‐bis(carboxymethyleneoxy‐phenyl]porphyrin (T3,4BCPP) was synthesised and efficiently labeled with 99m Tc. On injecting this 99m Tc labeled porphyrin to abdominal Sarcoma 120 bearing Swiss mice it accumulated in the abdominal tumour. This radiolabeled complex can thus be used for tumour detection and diagnosis.