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Extrahepatic drug metabolizing enzymes
Author(s) -
Kapitulnik Jaime,
Strobel Henry W.
Publication year - 1999
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/(sici)1099-0461(1999)13:5<227::aid-jbt1>3.0.co;2-1
Subject(s) - enzyme , drug , hormone , tissue distribution , transcription factor , biochemistry , transcription (linguistics) , biology , chemistry , pharmacology , gene , physiology , linguistics , philosophy
Drug metabolizing enzymes are known to be present and active in most extrahepatic tissues. In this review, evidence is presented that expression and activity of several extrahepatic drug‐metabolizing enzymes are regulated in unique ways, which may be associated with tissue functions and activities. In several instances evidence is offered that hormonal effects may be regulated through tissue specific distribution and/or responses of transcription factors. © 1999 John Wiley & Sons, Inc. J Biochem Toxicol 13: 227–230, 1999
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