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Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment
Author(s) -
Peterson Jayms D.,
Wolf Marina E.,
White Francis J.
Publication year - 2000
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(20000615)36:4<342::aid-syn11>3.0.co;2-9
Subject(s) - amphetamine , dopamine , prefrontal cortex , glutamate receptor , neuroscience , psychology , chemistry , medicine , receptor , cognition
Abstract Using in vivo extracellular single‐cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V‐VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine‐pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal. Synapse 36:342–344, 2000. Published 2000 Wiley‐Liss, Inc.