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Comparative genomic hybridization for genetic analysis of renal oncocytomas
Author(s) -
Presti Joseph C.,
Moch Holger,
Reuter Victor E.,
Huynh Danh,
Waldman Frederic M.
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199612)17:4<199::aid-gcc1>3.0.co;2-z
Subject(s) - comparative genomic hybridization , renal oncocytoma , biology , computational biology , evolutionary biology , genetics , kidney , genome , gene , oncocytoma
Abstract Renal oncocytomas are uncommon tumors of the kidney that are considered to be of low malignant potential. Neither conventional cytogenetic nor restriction fragment length polymorphism analyses have identified consistent genetic alterations in their genomic DNA. The purpose of the present study was to identify the genetic alterations associated with the development of renal oncocytomas. We studied 13 renal oncocytomas by using comparative genomic hybridization, and we identified loss of genetic material from chromosomes 1 and/or 14 in six of these tumors. These alterations may represent early genetic events in the development of these tumors. Genes Chromosom Cancer 17:199–204 (1996) . © 1996 Wiley‐Liss, Inc.