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Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma
Author(s) -
Hu LiFu,
Eiriksdottir Gudny,
Lebedeva Tatyana,
Kholodniouk Irina,
Alimov Andrei,
Chen Fu,
Luo Yan,
Zabarovsky Eugene R.,
Ingvarsson Sigurdur,
Klein George,
Ernberg Ingemar
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199610)17:2<118::aid-gcc7>3.0.co;2-8
Subject(s) - loss of heterozygosity , nasopharyngeal carcinoma , chromosome , long arm , genetics , biology , medicine , oncology , gene , allele , radiation therapy
Abstract We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1‐14.3) in 60% and D3S1217 (3p14.2‐14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages. Genes Chromosom Cancer 17:118–126 (1996). © 1996 Wiley‐Liss, Inc.