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Myasthenia gravis, thymoma, intestinal pseudo‐obstruction, and neuronal nicotinic acetylcholine receptor antibody
Author(s) -
Pande Ravi,
Leis A. Arturo
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199911)22:11<1600::aid-mus19>3.0.co;2-3
Subject(s) - thymoma , myasthenia gravis , acetylcholine receptor , medicine , intestinal pseudo obstruction , nicotinic acetylcholine receptor , nicotinic agonist , pathology , antibody , acetylcholine , receptor , immunology , gastroenterology
Intestinal pseudo‐obstruction occurs rarely in patients with myasthenia gravis (MG) and thymoma. The etiology of the intestinal pseudo‐obstruction remains to be elucidated, although an autoimmune mechanism is postulated. We present the first report of neuronal nicotinic acetylcholine receptor (AChR)–specific antibody in a patient with seropositive MG, malignant thymoma, and intestinal pseudo‐obstruction. This finding provides evidence that intestinal pseudo‐obstruction associated with thymoma and possibly other neoplasms may be related to antibodies against the neuronal nicotinic receptors at autonomic ganglia. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1600–1602, 1999
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