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Combined cytomorphologic and immunophenotypic approach to evaluation of effusions for lymphomatous involvement
Author(s) -
Dunphy Cherie H.
Publication year - 1996
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/(sici)1097-0339(199612)15:5<427::aid-dc14>3.0.co;2-p
Subject(s) - immunophenotyping , medicine , pathology , lymphoma , effusion , biopsy , pleural effusion , flow cytometry , radiology , immunology , surgery
Abstract Combining cytomorphology and immunophenotypic data in evaluation of effusions for lymphomatous involvement is reliable, non‐invasive, and expeditious. In this study, 30 effusion specimens from 30 patients with clinically suspected or previously diagnosed non‐Hodgkin's lymphoma (NHL) were evaluated cytomorphologically and by flow cytometric immunophenotyping with a large panel of monoclonal antibodies. Of 11 patients with a previous diagnosis of NHL, 50% had cytomorphologic and immunophenotypic evidence of lymphomatous involvement of effusion specimens; therefore, flow cytometric immunophenotyping is recommended in these cases since there may be substantial therapeutic impact. In addition, 69% of the effusions positive for lymphomatous involvement represented newly diagnosed NHL; in 36% of these cases, tissue biopsy was not necessary since they were either high‐grade (lymphoblastic or small, non‐cleaved cell type) or of the small lymphocytic lymphoma cell type. Diagn Cytopathol 1996;15:427–430. © 1996 Wiley‐Liss, Inc.