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Technetium‐99m methoxyisobutylisonitrile chest imaging of small cell lung carcinoma
Author(s) -
Kao ChiaHung,
ChangLai ShengPing,
Chieng PoonUng,
Yen TzuChen
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980701)83:1<64::aid-cncr9>3.0.co;2-e
Subject(s) - medicine , chemotherapy , nuclear medicine , etoposide , spect imaging , lung cancer , respiratory disease , p glycoprotein , carcinoma , lung , radiology , multiple drug resistance , drug resistance , microbiology and biotechnology , biology
Abstract BACKGROUND The purpose of this preliminary study was to evaluate retrospectively the relation between chemotherapy response and survival time, using technetium‐99m methoxyisobutylisonitrile (Tc‐99m MIBI) uptake in small cell lung carcinoma (SCLC) to detect the expression of multidrug resistance (mdr)‐mediated 170‐kDa P‐glycoprotein (PgP). METHODS Before the administration of chemotherapy (which consisted of cisplatin 25 mg and etoposide 125 mg every day per 3‐day course), 15 male patients (ages 54‐64 years) with SCLC were enrolled in this study to undergo Tc‐99m MIBI chest imaging, including single photon emission computed tomography (SPECT) and planar imaging, for qualitative and quantitative assessments of PgP in their SCLC. RESULTS In 12 of 15 cases (80%), SCLC could be detected by visual interpretation of the Tc‐99m MIBI chest SPECT images. In 13 of 15 cases (87%), Tc‐99m MIBI chest SPECT images (either positive SPECT with good response or negative SPECT with poor response) correctly predicted chemotherapy response. The correlation between tumor uptake ratios obtained by planar images (total counts in the region of interest [ROI] of the tumor divided by total counts in the same size ROI of the contralateral normal lung) and survival days (from the time of SCLC diagnosis to the time of the patient's death) was both positive and good (correlation coefficient = 0.83). CONCLUSIONS Tc‐99m MIBI chest images have the potential to demonstrate mdr‐PgP expression in SCLC and to predict patient prognosis and chemotherapy response. Cancer 1998;83:64‐68. © 1998 American Cancer Society.