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Fractionated radiotherapy of rat prostatic adenocarcinoma (Dunning R3327‐PAP) in nonanesthetized animals
Author(s) -
Granfors Torvald,
Bergh Anders,
Löfroth PerOlov,
Widmark Anders
Publication year - 1999
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19990401)39:1<16::aid-pros3>3.0.co;2-l
Subject(s) - radiation therapy , medicine , adenocarcinoma , prostatic adenocarcinoma , pathology , biology , cancer
Abstract BACKGROUND The dose‐response effect of fractionated external beam radiotherapy on nonanesthetized rats bearing the androgen‐sensitive prostatic adenocarcinoma Dunning R3327‐PAP was studied. METHODS The radiation was given with a photon beam from a 4‐MeV linear accelerator in doses from 4 to 11 Gray per fraction during 5 consecutive days. When the tumors with low and intermediate radiation doses relapsed into regrowth, the rats were castrated. Tumor volumes and rat weights were followed, and at the end of the study a morphometric analysis of the tumors was done. RESULTS Fractionated irradiation induced a dose‐dependent delay in tumor growth in hormonally intact rats. Castration stopped the tumor regrowth, showing that some of the tumor cells were still hormone‐sensitive. The study was facilitated by the nonanesthesia procedure. CONCLUSIONS The Dunning R3327‐PAP hormone‐sensitive rat tumor is sensitive to radiotherapy in a dose‐dependent way. Regrowing, irradiated tumors contain hormone‐sensitive cells. This work provided basic knowledge for further experimental studies of the effects of radiation on prostatic adenocarcinoma. Prostate 39:16–22, 1999. © 1999 Wiley‐Liss, Inc.