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Giant cell tumor of the tendon sheath: A retrospective study of 28 cases
Author(s) -
Rodrigues Callista,
Desai Sangeeta,
Chinoy Roshni
Publication year - 1998
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199806)68:2<100::aid-jso5>3.0.co;2-a
Subject(s) - giant cell , tendon sheath , medicine , histiocyte , pathology , joint capsule , lesion , giant cell tumors , hemosiderin , numerical digit , xanthoma , anatomy , tendon , arithmetic , mathematics
Abstract Background and Objectives: Giant cell tumor of the tendon sheath (GCTTS) is a lesion of uncertain etiology. To better interpret pathogenesis and aid in the differentiation of GCTTS from other similar pathological processes we reviewed the literature and analyzed the available information. Methods We retrospectively studied clinicopathologic findings in 28 cases of GCTTS on the basis of anatomic location and histologic appearance of the lesion. Results The GCTTS could be divided into those involving the common digits (20 cases) and larger joint group (8 cases) based on anatomic location. Grossly the digit tumors were small, multiple, surrounded by a thin fibrous capsule, and had a variegated appearance, while the large joint tumors were relatively large and covered by one or more layers of synovium. Microscopically both groups consisted of a mixture of round to polygonal histiocytes, foam cells, hemosiderin laden macrophages, and multinucleated giant cells. The giant cells seemed more abundant in the digit tumors, while the pseudoglandular spaces lined by synovial cells were more striking in the large joint group. Conclusions Local excision was the treatment of choice in the majority of the patients. Eight patients had local recurrence. J. Surg. Oncol. 1998;68:100–103. © 1998 Wiley‐Liss, Inc.