Meningiomas in Lymphangioleiomyomatosis | Zendy

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Meningiomas in Lymphangioleiomyomatosis

Author(s) -

Joel Moss

Publication year - 2001

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.286.15.1879

Subject(s) - medicine , lymphangioleiomyomatosis , meningioma , tuberous sclerosis , magnetic resonance imaging , lung , radiology , progesterone receptor , pathology , cancer , estrogen receptor , breast cancer

Lymphangioleiomyomatosis (LAM), a cystic lung disease associated with progressive respiratory failure, is found predominantly in women of childbearing age and therefore has been treated with progesterone and other hormonal agents. However, meningiomas have progesterone receptors, and progesterone is believed to be a mitogen for meningioma cells in culture. Since 30% to 40% of patients with tuberous sclerosis complex (TSC) have LAM, we routinely screen patients with LAM for brain lesions found in TSC.

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