In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging | Zendy

George Bartzokis | Zendy; David L. Sultzer | Zendy; Jeffrey L. Cummings | Zendy; Lori E. Holt | Zendy; Darwood B. Hance | Zendy; Victor W. Henderson | Zendy; Jim Mintz | Zendy

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In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Author(s) -

George Bartzokis,

David L. Sultzer,

Jeffrey L. Cummings,

Lori E. Holt,

Darwood B. Hance,

Victor W. Henderson,

Jim Mintz

Publication year - 2000

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.57.1.47

Subject(s) - globus pallidus , putamen , basal ganglia , ferritin , magnetic resonance imaging , white matter , caudate nucleus , medicine , pathology , chemistry , endocrinology , psychology , central nervous system , radiology

The basal ganglia contain the highest levels of iron in the brain, and postmortem studies indicate a disruption of iron metabolism in the basal ganglia of patients with Alzheimer disease (AD). Iron can catalyze free radical reactions and may contribute to oxidative damage observed in AD brains. Treatments aimed at reducing oxidative damage have offered novel ways to delay the rate of progression and could possibly defer the onset of AD. Brain iron levels were quantified in vivo using a new magnetic resonance imaging method.

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