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After injury, if regeneration can be observed in hydra, planaria and somevertebrates, regeneration is rare in mammals and particularly in humans. Inthis paper, we investigate the mechanisms by which biological tissues recoverafter injury. We explore this question on adipose tissue, using themathematical framework recently developed in Peurichard et al, J. Theoret.Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cuesbetween the Extra-Cellular Matrix (ECM) and differentiated cells can explainadipose tissue morphogenesis and that regeneration requires after injury thesame mechanisms. We validate this hypothesis by means of a two-dimensionalIndividual Based Model (IBM) of interacting adipocytes and ECM fiber elements.The model successfully generates regeneration or scar formation as functions offew key parameters, and seems to indicate that the fate of injury outcome couldbe mainly due to ECM rigidity.

Extra-cellular matrix rigidity may dictate the fate of injury outcome