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Mikhail Shapiro's lab investigated a promising new method for non-invasivecontrol of calcium currents in individual cells in the nervous system by theselective heating of nanoparticles and show that simple physical laws, properlyapplied, explain what is happening, and so can be a foundation for constructingimproved methods and techniques. They use custom built instrumentation anddetailed quantitative measurement to show that special surface properties arenot needed to explain their results. Their work is taken as an example of theneed for quantitative measurement in biophysics and biology in general.Classical examples are cited and the argument is made that the success ofstructural and molecular biology has hidden the need for quantitativemeasurements and controls. Semiconductor and computational electronics is citedas a science even more successful than structural and molecular biology thatdepends on quantitative measurement, controls, and analysis.

Energetic Controls are Essential: New and Notable Note for Biophysical Journal