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A simple UV-visible spectroscopic method was developed and Chemometric designs were applied for the simultaneous estimation of Etophylline (ETO) ,Theophylline (THEO) in bulk and solid dosage form. The spectroscopic method was developed by using methanol as solvent for the two drugs and the data generated from the spectra were mined by using Chemometric methods such as bi-linear regression analysis, Cramer’s matrix method and Method of least squares.The wavelengths selected for all the above methods were 271 nm (wavelength of maximum absorption; λmax of ETO), 273 nm (wavelength of maximum absorption; λmax of THEO). Results: The methods hold good linearity for ETO from 5-9μg/ml, for THEO from 1-5μg/ml with regression coefficient values of 0.999/ 0.998 respectively. The RSD for interday and inter-day precision was found to be less than 2% . The percentage recovery and percentage assay was in the range 95-115% Of for Etophylline (ETO) and Theophylline (THEO) by all the methods. Conclusion: The developed methods neither require any cumbersome separation procedure nor complex derivatization procedures for the analysis of the two drugs and moreover they are effective in minimizing the errors in analysis, simple and economical.

Simultaneous Estimation of Etophyllineand Theophylline in Bulksolid Dosage Form by Chemo Metric Assisted Spectrophotometric Methods