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Solvent free and simple one-pot synthesis for three-component protocol has been used for efficient synthesis of new mannich products (HB7-B12) in excellent yields from heterocyclic aldehyde, phenol as uv absorbing material and various amide derivatives with using Ethyl ammonium nitrate ( reusable ionic liquid) as catalyst under 80 0 C temperature. All synthesized compounds were characterized by 1 H-NMR, 13 C NMR spectra and screened for their in vitro antibacterial activity by using the agar dilution technique. Specially two compounds shows very good microbial activity as Shown by standard drugs, HB9 and HB10 compounds showed potential activity especially against E. Coli MTCC 443 (MIC =45-50 µg/mL) P. Aeruginosa MTCC 1688 (MIC =45-50 µg/mL) and S. Aureus MTCC 96 (MIC=45-50 µg/mL). All compounds HB7-12 shows very good activity but HB9 and HB10 compound shows excellent antifungal activity between 75-100 µg/mL which is most active rather than Greseofulvin. Antituberculosis activity of HB9 and HB10 compounds shows good activity 1 µg/mL using L. J. medium conventional Method.

Design, synthesis and biological evaluation of new Mannich products using ethyl ammonium nitrate as reusable ionic liquid