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Since Pityriasis rosea has often been linked to upper tract respiratory infections and an increased incidence is reported among groups with close physical contact (eg, families, students, and military personnel), since ampicillin increases the distribution of the eruption, an effect bearing a striking resemblance to the drug's effect on the rash of some types of infections and substantially PR occurs often in co-presence with Acne vulgaris (that is characterised besides of inflammatory factors from the presence and activity of the commensal bacteria Propionibacterium acnes, I have attempted to combat radically two important cases of PR (Vidal's circinata and Hardy's disseminate and urticata), employing clotrimazole at very low concentrations, as this drug is able to substantivate to skin keratin and act as a drastic antibiotic against Gram +. Keywords: Gilbert's Pityriasis rosea, Vidal's PR circinata, Hardy's PR disseminata ,clotrimazole, panthenol,

Clotrimazole used as antibacterial instead of antimycotic in two cases of Gilbert’s Pityriasis rosea in association with allantoin and panthenol.