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There has been growing interest in studying the role played by lipid peroxidation and antioxidant status in breast cancer Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis. In the present study,effects of both ellagic acid and paclitaxel on the levels of lipid peroxides(LPO) and status of antioxidants in several tissues were studied in mammary carcinoma rats. The levels of reactive oxygen species (ROS) were also measured in control and experimental animals.A significant increase in the levels of LPO,ROS and a decreased levels of antioxidants observed in mammary carcinoma bearing rats were found to be reverted back to near normal levels on treatment with both paclitaxel and ellagic acid.These results suggest that the free radical mediated damage during mammary carcinoma could have been controlled by both ellagic acid and paclitaxel by its free radical quenching and antioxidative potential.The above results also show that both paclitaxel and ellagic acid exert its anticancer effect on the development of breast cancer. Keywords: Ellagic acid , Breast cancer, LPO, Reactive oxygen species.

Anticancer effect of Ellagic acid and paclitaxel on Lipid Peroxidation and Antioxidant status in female Sprague dawley rats