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Biomarker approach is to improve screening, detection and the diagnosis of early-stage prostate cancers. Over diagnosis and false positives present significant clinical problems in the prevention and treatment of cancer. Therefore, there are unmet needs to more accurately identify early-stage cancers and distinguish lesions that are life threatening from those that are not. Sarcosine was used as a model analyte in this study due to its potential for serving as a prostate cancer metabolomic marker. The normal concentration of Sarcosine in the blood is below limit of detection and remains undetermined (Bellon, 1984). Therefore, bio-fluid urine was selected for the analysis purpose. Based on the literature, initially standardization of Sarcosine was carried out. Thereafter, prostate cancer patients' urine samples of various stages are analyzed in order to detect and analyze prevalence of biomarker with progression of the disease.

Sacosine As A Stage Dependant Metabolomic Marker To Detect Prostate Cancer By Using Hptlc