English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Diabetes is a multisystem disorder marked by elevated blood sugar level. It has been estimated that the global burden of type 2 diabetes mellitus (T2DM) for 2030 is projected to increase to 438 million ; a 65 % increase. During diabetes, persistent hyperglycemia causes increased production of free radicals especially reactive oxygen species (ROS) as by-products of normal cellular metabolism. The chronic hyperglycaemia, insulin resistance and abnormal lipoprotein profiles found in diabetes may contribute to a decrease of bioavability of vascular nitric oxide (NO), impairing endothelium- dependent vasodilatation documented in and in humans with diabetes. Oxidized LDL may contribute to the progression of atherosclerosis by enhancing endothelial injury.Extracts of chirata reduced LDL oxidation by about 40% which is very close to the efficacy of Atorvastatin (reduction by 51.72%).The management of diabetes nephropathy is extremely expensive and frustrating. Therefore, prevention is better. Sources of antioxidants, especially antioxidant vitamins are available and affordable in most environments. In present investigation aqueous and ethanolic Swertia chirata, increased total antioxidant power of normal plasma by 1.484 and 1.84 fold,and in diabetics it increased by 1.25 fold and 2.19 fold respectively. Extracts of chirata are also very effective in reducing MDA formation in plasma,also these are free of side effects and very cost effective.

Impact of Swertia chirata extract on prevention of Cu2+ LDL oxidation and malondialdehyde formation