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The effects of cataflam, aspirin and the ethanolic extract of Cannabis sativa on nociception was studied in albino mice of both sexes. Forty (40) albino mice were divided into four (4) groups of ten (10) each. The control group was given normal saline (p.o). Test group one (1) was given (p.o) cataflam at a dose of 1.5mg/kg. Test group two (2) was given (p.o) aspirin at a dose of 13.5mg/kg. Test group three (3) was given the ethanolic extract of Cannabis sativa at a dose of 10mg/kg. All four (4) groups were given access to normal mice chow and water ad libitum. The hot plate test was used to assess the effects of the test substances on sensitivity to acute thermal pain while the formalin test was used to assess the sensitivity to persistent pain due to peripheral tissue injury and inflammation. The result shows that Cannabis, Cataflam and Aspirin all reduce sensitivity to pain. This is indicated by the reduction in frequency and duration of hind paw licking in both phases of the formalin test (p<0.05). Cataflam and Cannabis may not have any effect on sensitivity to acute thermal pain. There was no significant difference in the latency of jump in the groups treated with Cataflam and Cannabis during the hot plate test compared to control (p<0.05). But they all reduce sensitivity to persistent inflammatory pain.

Comparative Effect of Cannabis, Aspirin and Cataflam on Nociception in Cd1 Mice