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Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression and prophylaxis of bipolar disorders. The aim of present study was to observe histological changes in the liver of lithium carbonate treated Albino rats. Sixty albino rats were taken and divided into two groups, group A (control group) of 15 animals, were fed with normal diet and group B of 45 animals, were fed normal diet along with lithium carbonate at the dose of 30mgs/kgm body weight daily. The animals were sacrificed at four, eight and twelve week's interval, liver excised, 5µm thick sections prepared and stained with Haematoxylin and Eosin stain. On microscopic examination, as drug treatment continued the capsule remained intact, there was hepatic degeneration, followed by necrosis and cyst formation. There was Kupffer cell hyperplasia, central vein congestion and portal triads were infiltrated with lymphocytes and plasma cells. Liver parenchyma was infiltrated with lymphocyte, giving hepatitis like picture. It can be concluded that Lithium carbonate on long term treatment in rats causes hepatic degeneration, hepatitis and necrosis. So, it is advised that patients on lithium therapy should be periodically evaluated for hepatic dysfunction.

Lithium carbonate induced Histological changes in the Liver of Albino Rats