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5-Fluorouacil, Adriamycin (doxorubicin) and Cyclophosphamide (FAC) is one of the major chemotherapy options for breast cancer. Objective: the aim of this article is to investigate the effect of FAC chemotherapy on the blood insulin concentration. Methods: 28 breast cancer patients and 28 normal subjects were involved in this study after informed consent. 5 mls of intravenous blood samples were obtained from the control subjects and from the patients at diagnosis time (before starting chemotherapy) and after chemotherapy. The insulin concentration was measured using Immuno Radio Metric Assay (IRMA). Results:all the study subjects were females and their age ranges were 26- 65. Half of study subjects received 3 cycles of FAC therapy and the rest received 6 cycles. The insulin concentration range, mean and standard deviation of the control subjects, patients before receiving the therapy and patients after receiving the therapy were (4- 16.8, 9.74 and 3.74), (4.1- 56.7, 17.53 and 11.04) and (5.6- 58, 22.94 and 11.31). However, 12 of the patients were with high insulin concentration (hyperinsulinemia) compared to the control subjects and the FAC therapy increased the number of patients with high insulin concentration to 21. When the mean of insulin of the control subjects was compared to the means of insulin in the patients pre and post treatment, it was clear that breast cancer was associated with significant increase in insulin concentration since the p- value was 0.001 and the FAC therapy significantly increased the insulin concentration (p- value ≤ 0.000). When the mean of insulin concentration in the patients before treatment was compared to its mean after FAC therapy, the p- value was equal to 0.057. Conclusion:12 (42.9%) of the newly diagnosed breast cancer patientswere associated with hyperinsulinemia and the FAC therapy increased the number of patients with hyperinsulinemia to 21 (75%) i.e. the FAC therapy increased the insulin concentration.

Effect of FAC Chemotherapy on Plasma Insulin Concentration