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Coronary Artery Disease (C.A.D.) occurs due to blockage of Coronary arteries by atheroma, leading to inadequate blood supply to heart muscle compared to its need. Manifestations of C.A.D. vary from angina, Myocardial Infarction (M.I.) arrhythmia to sudden death. Oxidative modification of lipoproteins due to lipid peroxidation by free radicals will enhance atheroma formation, aggravating C.A.D. and leading to M.I., the severity of which can be assessed by MALONDIALDEHYDE (MDA) estimation.AIM OF STUDY:The aim of present study is whether MDA level can be used as marker of M.I. and to see whether the different risk factors like smoking, Hypertension (HTN), Diabetes Mellitus (DM), Obesity and Alcohol causing peroxidative damage and dyslipoproteinemia will show additive effect in relation to MDA levels.MATERIALS AND METHODS:The study population consisted of 3 groups of subjects. Group I – Cases with coronary risk factors and with M.I.Group II – Cases with coronary risk factors, but without M.I. Group III – Healthy Normals. In these 3groups Lipid profile and Serum MDA level was estimated by Thiobarbituric acid method.RESULTS:Lipid peroxidative damage is found to be associated with all the Risk Factors studied namely HTN, D.M., Obesity, Alcohol and Smoking either singly or in different combinations as evidenced by elevation of MDA, Triglycerides, total cholesterol and LDL cholesreol and a fall of HDL.CONCLUSION:C.A.D. is a multi factorial process, with no individual factor strictly essential or sufficient for causation of M.I. In-variably the hazard posed by any particular risk factor is markedly influenced

iosr journal of pharmacy and biological sciences

Comparative Study of Malondialdehyde Levels and Lipid Profile in Patients with Myocardial Infarction and In Individuals without Myocardial Infarction, But With Coronary Risk Factors.