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Human immuno deficiency virus is a lentivirus (slowly replicating virus) that cause acquired immuno deficiency syndrome “(AIDS ). HIV attached to the human CD4 receptor and leads to the infection. The most notable, the T-helper cells which plays a central role in immune response are disabled and killed during the typical course of infection.HIV-2 infection is characterised by higher CD4 cell count & lower viral RNA level. The main objective of this project work is to find out potential compound that can help to interrupt the function of HIV-2integrase (IN) protein. In this study, we employed the integrase protein sequence to build suitable drug by homology modeling , which has been checked for high reliability by verify score ,energy minimization for stability and active side prediction. Its accuracy has been verified by the Saves server and Ramachandran plot. The model structure was employed for docking. Known inhibitor taken from the literature docked, and docked at the binding site. Obtain molecule 2'-Deoxyuridylic acid,2-(Ethoxymethyl)-4(4-Fluorophenyl)-3-[2-(2-Hydroxyphenoxy)Pyrimidin-4-yl]isoxazol-5(2H)-one,{4-[2,2-BiS(5 methyl-1,2,4oxadiazole-3-YL)-3-phenyl pyro]phenyl}sulfamic acid,2-(2-{2-[(Biphenyl-4-ylmethyl)-amino]-3-Meracaptopentanoylamino}-acetylamino)-3-methyl-butaric acid methyl ester, N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin7-yl)-2-methylpropyl]-4-phenoxybenzamide have been given score of -136.401 kcal/mol , -143.584 kcal/mol , 136.863 kcal/mol , -135.008 kcal/mol , -156.243 kcal/mol.

“Analysis of binding properties of integrase protein to find out potential drug candidate for HIV-2 through insilico molecular docking ”