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The effect of marijuana and tobacco leaves on male albino rats haematological and liver functional indices were investigated. Twenty (20) male albino rats were randomly grouped into four (4) A, B, C and D. Rats in B, C and D were administered with marijuana, tobacco and mixture of marijuana and tobacco respectively in the ratio 3:1 after an acclimatization period of 7 days. Rats in group A served as the control and were administered with standard feeds and water only. Their weights were monitored on daily bases with their consumption rate inclusive. The rats were sacrificed after an experimental period of 14 days. The haematocrit (PCV) and haemoglobin concentration showed a significant decrease (p<0.05). Total protein produces a significant increase (p<0.05) with rats administered with marijuana while tobacco and mixture of tobacco and marijuana shows a significant decrease (p<0.05). Albumin gives a significant decrease (p<0.05). Globulin produce an increase (p<0.05) in for both marijuana and tobacco but modulates a decrease (p<0.05) in mixture of tobacco and marijuana, serum AST and ALP produce a significant increase (p<0.05) with marijuana and mixture of marijuana and tobacco. A significant increase (p<0.05) was observed from liver AST and ALP. A drastic reduction was observed in weight of rats administered with marijuana, tobacco and mixture of marijuana and tobacco. The alterations in haematological and liver function indices are indications of dishaematopoetic potential, pathological condition and impairment on the liver.

Assessment of the Effect of Cannabis sativa and Nicotiana tobacumLeaves on some Haematological and Liver Function Indices of Albino Rats.