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The aim of this present study is to investigate central nervous system activity of the methanol extract of leaves of Solanum pubescens in Swiss Albino mice and Wistar albino rats. Solanum pubescens is a traditional medicine plant for the treatment of Hypoglycemic, Anti-bacterial & Anti-HIV activities. The work reached the acute toxicity studies solanum pubescens and its action on the central nervous system, because no data in the literature have been found of pharmacological activity of this plant in the central nervous system. The leaves was extracted with methanol and investigated for its central nervous system activity of Albino mice in Rota-rod and Actophotometer at the dose level of 300mg/kg. The extract exhibited significant central nervous system activity. This study established central nervous system activity in Solanum pubescens leaves. It has been concluded that methanolic extract of Solanum pubescens exhibited Anxiolytic, Myorelaxant & Anti-depressant activity.

CNS Activity of the Methanol Extracts of Solanum Pubescens in Experimental Animal Model