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Jatropha tanjorensis leaf serve both as food and as medicine. There is need for proper physiological and toxicological tests in order to ensure its safety. The analyses of nitrogenous wastes produced on exposure of Clarias gariepinus to the acute concentration (0.0, 2.0, 4.0, 6.0, 8.0 and 10.0g/L) of aqueous extracts of Jatropha tanjorensis leaf was studied for four days. The result of the nitrogenous wastes parameters showed that serum bilirubin and uric acid, creatinine and urea were significantly higher (P < 0.05) in the injected fish, while muscle and kidney bilirubin, and kidney uric acid was significantly lower (P < 0.05). The nitrogenous wastes activities of C. gariepinus were both dose and tissue dependent. This study highlights the fact that acute concentrations of aqueous extracts of Jatropha tanjorensis have moderate deleterious consequences on the nitrogenous wastes activities of Clarias gariepinus.

iosr journal of pharmacy and biological sciences

Alterations in the Activities of the Nitrogenous Wasteof Clarias Gariepinus after Intramuscular Injection with Aqueous Extracts of Jatropha Tanjorensis Leaves.