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Background: Diabetic nephropathy is a common complication of diabetes mellitus type2. Glycated albumin level increase in states of abnormally high glucose concentration in diabetes mellitus. The increase in concentration glycated albumin plays role in diabetic nephropathy through stimulation of collagen and fibronectin expression in mesangial cell. Objective: This study aimed to evaluate the roles of the serum glycated albumin as predictor of diabetic nephropathy with type2 diabetic patients with normal albuminuria , micro albuminuria and comparing them with normal healthy subjects . Method : This study was conducted in Medical City, Baghdad Teaching Hospital during the period from December 2015 to June 2016.The study included (90) subjects with age range between (30 – 56) years, divided in to three groups , 30 healthy control, 30 type 2 diabetic mellitus patients with normal albuminuria (micro albumin < 30 μg/ml ) and 30 type2 diabetic mellitus patients with micro albuminuria (micro albumin >30 μg/ml ).Body mass index (BMI) was determined, Fasting blood sugar (FBS) ,serum creatinine ,blood urea ,and glycated hemoglobin (HbA1c%) were measured for each individual in addition to the concentration of albumin in urine and estimation glomerular filtration rate (eGFR) was calculated. Results : The results of the present study showed that the levels of fasting blood sugare , HbA1c %,blood urea ,and serum creatinin, were significantly higher in micro albuminuria than normal albuminuria and healthy control and Glycated Albumin(GA%) levels showed a statically significant difference (p <0.05) among the studied groups ,it was significantly higher in group micro albuminuria than group normal albuminuria when compared with healthy control group (19.0±5.7), (17.1±5.1), and (15.6±4.6) respectively. Conclusion: Diabetic patient with micro albuminuria show increase the level of serum GA % which may be considered as predictor of diabetic nephropathy . Keyword: diabetic nephropathy, micro albuminuria, serum albumin, Glycated Albumin (GA%)

Role of Glycated Albumine as a Predictor of Nephropathy in Type 2 Diabetic Iraqi Patients