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Aim of the study: Evaluation of influence of the corneal collagen cross-linking (CXL) on concentrations of selected cytokines and metalloproteinase 2 in a tear film. Prospective study with a control group. Methods: 31 eyes of 31 patients, with confirmed KC, were qualified into the study and underwent a collagen cross linking procedure. Samples of tear film (100μl) were collected after 6 weeks from the procedure using spongostan sticks. After centrifugation, the acquired material was tested using high sensitivity ELISA. Results: In study group before CXL concentrations of IL-1b, IL-6, IL-10, MMP-2 equaled respectively: 151 ± 42, 24 pg/ml, 7,44 ±1,4 pg/ml, 15,88± 2,01 pg/ml, 17,49±2,49 ng/ml. After CXL their levels equaled: 35,32 ± 13,72 pg/ml (p<0,01), 17,73± 5,31 pg/ml (p<0,01), 16,17 ± 2,15 pg/ml (p>0,05), 30,71± 3,88 ng/ml (p<0,01). There was statistically significant correlation between levels of IL-1b and MMP-2 (r=-0,5; p<0,01). Conclusions: Outcomes seem to confirm the hypothesis that inflammation is an essential component of multifactorial etiology of KC. CXL procedure leads to decrease in IL-1b levels and increase in IL-6 and MMP-2 levels in the tear film of patients with KC, after six weeks from procedure. There was a statistically significant negative correlation between Il-1b and MMP-2. Evaluation of corneal cytokines may be utilized as the prognostic factor of KC progression. Date of Submission: 28 November 2016 Date of Accepted: 15 February 2017

Influence of the Corneal Collagen Cross-linking on Levels of Il- 1b, Il-6, Il-10 and MMP-2 in the Tear film of Patients with Keratoconus.