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Background: This study was conducted to determine postoperative pain control with use of Bupivacaine soaked sheet of Regenerated Oxidized Cellulose (ROC) in gallbladder (GB) bed and compared with port-site infiltration of bupivacaine after Laparoscopic Cholecystectomy (LC). Methods: Total 100 patients were divided in 3 groups. In Group A (n=37) Bupivacaine soaked ROC was positioned in the gallbladder bed. In Group B (n=28) Bupivacaine was infiltrated in trocar site before skin suturing and in Group C (n=32) was control group. Nature of pain, either visceral, parietal, or shoulder, was assessed on Visual Analogue Scale( VAS) at 3, 6, and 24 hours after surgery. Results: All patients (100%) demonstrated different intensities of visceral and parietal pain in all groups. None of the patients had shoulder pain. Visceral pain was significantly less in Group A as compared to Group B and C (p<0.05). Visceral pain score for Group A at 3, 6, and 24 hours assessment was 17.41%, 21.76%, and 19.02% which was significantly less than Group B (37.69%, 29.39%, and 33.21%) and Group C (51.63%, 49.87%, and 50.29%). Parietal pain score for Group B at 3, 6, and 24 hours assessment was 17.35%, 16.67%, and 17.02% which was less than Group A ( 24.57%, 25.32% and 26.34%) and Group C (49.33%, 49.27%, and 51.22%) (p<0.05). In Group A 10 patients (27%) required postoperative analgesics within 10 hours of postoperative period. While in Group B 14 patients (50%) and Group C 32 patients (100%) required postoperative analgesia within 8 hours of postoperative period. Conclusion: Bupivacaine with ROC in the gallbladder bed is safe, technically simple, increases postoperative comfort, and decreases postoperative analgesic requirement after LC as compared to trocar site infiltration.

iosr journal of dental and medical sciences

Comparison of Pain Relief By Placing Regenerated Oxidized Cellulose Sheet Soaked in Bupivacaine And Port Site Infiltration With Bupivacaine Post-Laparoscopic Cholecystectomy: A Randomized Control Trial