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Endometrial cancer is the most common gynecologic malignancy in the United States. According to 2014 cancer statistics an estimated 52,630 cases of endometrial cancer and 8,590 of deaths cases are diagnosed in 2014.The classically diagnosis of endometrial cancer is abnormal vaginal bleeding. Most patients with this type of cancer have source of excess estrogen, high body mass index (BMI) as overweight or obese and often with other components of metabolic syndrome like hypertension.The aim of this study is investigate the role of hormonal balance and BMI in women patients with endometrial cancer. Fifty six endometrial cancer women patients mean aged (58.055 ± 10.561 years) not submitted to therapy in this study, and (n=30) healthy women volunteers mean aged (39.731 ± 13.504 years) as control group. The results in this study revealed a highly significant increased (P<0.01) in Estrogen (pg/mL) and Progesterone (ng/mL), BMI (Kg/m2), WHtR , and WHpRin the sera levels of patients with endometrial cancer as compared to control group. The results of this study showed the risk of endometrial cancer increases linearly with increasing BMIandalso showed the association between BMI and imbalances of sex steroid when there is deficient Progesterone or excessive Estrogen with endometrial cancer women patients. Keyword: Endometrial cancer, Estrogen (E2), Progesterone (P4) andBMI.

The Association between Hormonal Balance and BMI in Iraqi Women with Endometrial Cancer