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Background: Many infertile couples worldwide resort to donated gametes to overcome their infertility problems, however many others cannot for cultural or religious reasons. They have no other options but probably to keep trying In-Vitro Fertilization (IVF) treatment using their own gametes. We wanted to see if we would be able at some point to help such cases fulfil their dreams. Case Report: Four infertility cases with a history of many unsuccessful IVF trials; eight, seven, six, and four, suggestively because of very poor fertilization and/or poor embryo development due to sever male factor that ranged from azoospermia to severe oligo-terato-asthenozoospermia. Yet, in their subsequent trials we managed to help them conceive with live births at the end. Conclusion: In some complex infertility cases, when the use of donor-gametes is not an option, probably persistent hopefulness in IVF treatment with autologous gametes stays as the solution.

Successful in vitro Fertilization Using Autologous Gametes after Eight Failed Trials