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Objective: To study and analyze the causes for the failure of Anti epileptic treatment in children with seizure disorder in relation to age, sex, type of seizure and possible etiology. Design: Prospective observational cross sectional descriptive study. Setting: Children between 1-14 years who are suffering with recurrent seizures who are taking AEDs were taken for the study for a period of 6months (from Jan 2011 to June 2011) who were admitted in emergency and pediatric wards of Institute of Child and Women Health, Niloufer Hospital, Osmania Medical College, Hyderabad. Participants: Over a period of 6 months, 120 children between 1 14years were admitted in the hospital, were included and 3 were excluded because they are lost to follow up. Methods: All children with recurrence of seizures who are admitted pediatric wards and in emergency were constitute the study sample. The factors causing the recurrence of seizures were studied in the preset proforma. A thorough clinical examination of the study sample is done and including the relevant investigations. The data was analyzed statistically by using ODDS Ratio, and Relative Risk ratios, Chi-square test. For all children with seizures EEG and CECT were done. Age below1 year, above 14 years, any episode without antiepileptic treatment and Myoclonic seizures, Cerebral plasy with more than 1 Anti epileptic drug, Neurocutaneous syndrome, Lenox Gestaut syndrome, West syndrome were excluded from the study. Results: This study is comprised of 120 children (76 were male and 44were female) out of which 80(66.67%) children suffered with GTCS, 33(27.5%) suffered with complex partial seizures and remaining 7(5.83%) with atypical febrile seizures. Noncompliance is more common in more than 6 years children than less than 6 years. The p value is 6 years and the odds ratio is 1.69.GTCS type of seizures is more common recurrence in the age of above 6 yrs than below 6 yrs age group. The RR is 1.29in above 6 years. Conclusions: Male children were more commonly get recurrence of seizures (63%). Phenytoin drug users were more likely to get the recurrence of seizures.

Study on analysis of the causes for the failure of Antiepileptic treatment in children with seizure disorders in a tertiary centre.