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Background : Selective in-vivo anti-fungal action of Potassium iodide (KI) is an enigma, but circumstantial evidences strongly indicate some immune mechanism. Aim : To demonstrate in-vitro immune-modulating role of KI. Materials & methods : 31 sample ( patient sera) collected for the detection of ANA (Anti-nuclear Abs) of the IgG serotype. Taking the positive sample, for each time ,KI solution (0.4%) was given at a different step ( before the addition of conjugate, substrate , before & after the addition of doubly diluted patient sera ) of the assay procedure, to note any significant change in the final O.D. reading, which is directly proportional to the antibody activity in the sample. Procedure repeated for five times & the average result was considered. Procedure repeated with inert carbon particles showed no visible change in O.D. value. Results : KI when introduced after addition of the doubly diluted patient sera ,the graphical interpretation showed that with increasing 2-fold serial dilution of patient sera, the corresponding O.D. read at 450 nm, almost showed a steady fall. Conclusion: KI probably imparts it’s immune-modulating action by structural reformation of Ig molecule, explained in terms of affinity, that decreases proportionately with increasing 2-fold serial dilution of patient sera, with steady fall in the O.D. reading. Such immune-modulation may be related with therapeutic efficacy of this drug when used for clinical conditions, particularly, when no direct anti-microbial role of iodide is established.

The immune-modulating role of Potassium iodide on an ANAEase ELISA mode taking a positive sera for ANA (Anti-nuclear Abs) of the IgG isotype