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Objective The purpose of this study was to determine the prognostic significance of preoperative neutrophil-lymphocyte ratio for disease-free survival and overall survival in patients with stage II colorectal cancer. Summary of Background Data Previous reports have indicated an association between neutrophil-lymphocyte ratio and poor prognosis and tumor progression in patients with colorectal cancer. However, the role of neutrophil-lymphocyte ratio as a prognostic marker specifically in patients with stage II colorectal cancer has not been well studied. Methods A total of 124 patients with colorectal cancer were included in this study. The disease-free survival and overall survival of patients were compared using preoperative neutrophil-lymphocyte ratio. Univariate and multivariate analyses using the Cox proportional-hazards model were performed to determine the prognostic significance of neutrophil-lymphocyte ratio. Results The overall survival and disease-free survival rates of patients with a neutrophil-lymphocyte ratio ≥ 4.0 were significantly lower than those of patients with a neutrophil-lymphocyte ratio &amp;lt; 4.0. Multivariate analysis showed that a neutrophil-lymphocyte ratio ≥ 4.0, performance status ≥ 1, and depth of tumor invasion (T4) were independent prognostic factors for disease-free survival, whereas age &amp;gt; 80 years, a neutrophil-lymphocyte ratio ≥ 4.0, and performance status ≥ 1 were independent prognostic factors for overall survival. Conclusion Neutrophil-lymphocyte ratio is an independent poor prognostic factor in patients with stage II colorectal cancer undergoing curative resection.

Significance of Neutrophil-Lymphocyte Ratio (NLR) as a Prognostic Factor in Stage II Colorectal Cancer