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Introduction: Sickle cell disease causes chronic anemia with the need for transfusions. The risk in children to get transfusions transmitted infections is high. Aims: Determine the prevalence of HBsAg and HCV antibodies in sickle cell disease children under sixteen in Lome (Togo). Original Research Article Dossim et al.; MRJI, 30(1): 56-61, 2020; Article no.MRJI.54367 57 Study Design: It is a cross-sectional study. Place and Duration of Study: Sample: Haematology Unit of Campus University Hospital and Paediatric Unit of Sylvanus Olympio University Hospital of Lomé collected between February to May 2016. Sample processing: Campus Hospital Laboratory. Methodology: We collected blood in sickle cell disease patients in Campus and Sylvanus Olympio university hospitals at Lomé and informations about sickle cell type, transfusion, and hepatitis B vaccination. Sera were tested with Cobas e411 Roche® in the determining of hepatitis B surface antigen (HbSAg) and hepatitis C antibodies (HCVAb). Epi Info was used for statiscal analysis ®. Significant associations were found when P<0.05. Results: Total of 172 patients from Campus Hospital and 79 from Sylvanus Olympio were included. Sex ratio and SS phenotype were 0.93, 69.8% and 1.32, 64.5% respectively. HBsAg was detected in 1.7% from Campus and 7.6% in Sylvanus Olympio. One patient from Campus carried HCVAb. Significant association between hepatitis B and sex (P=0.02) and hepatitis B and vaccination were found (P= 0.0003). Males were more infected and patients who were unvaccinated carried HBsAg. Conclusion: Vaccination against viral hepatitis and best blood donation screening are necessary to avoid these viral diseases in sickle cell disease children.

Prevalence of Hepatitis B Surface Antigen and Hepatitis C Antibodies in Sickle Cell Disease Children under Sixteen in Two University Hospitals of Lome