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S&T FOODS Co. LtdAbstract This study aimed to investigate the anti-amnesic effect of perilla oil against trimethyltin (TMT)-inducedlearning and memory impairment in ICR mice. Perilla oil (2.5 mL/kg of body weight) and soybean oil (2.5 mL/kg of bodyweight) were administered orally to mice for 3 weeks, and at the end of the experimental period, cognitive behavior wasexamined by Y-maze and Morris water maze (MWM) tests. Behavioral tests showed that the mice treated with perilla oilhad improved cognitive function compared to that in mice administered soybean oil. Analysis of brain tissue showed thatperilla oil significantly lowered acetylcholinesterase activity and malondialdehyde (MDA) levels. Oxidized glutathione(GSH)-to-total GSH ratio also decreased from 10.4% to 5.3% in perilla oil-treated mice, but superoxide dismutase (SOD)activity increased from 11.7 to 14.2 U/mg protein. Therefore, these results suggest that the perilla oil could be a potentialfunctional substance for improving cognitive function.Keywords: acetylcholinesterase, cognition, perilla oil, soybean oil

Amelioration of Trimethyltin-induced Cognitive Impairment in ICR Mice by Perilla Oil