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Homogentisic acid which accumulates due to homogentisic acid oxidase enzyme deficiency causes joint cartilage damage which then, together with ageing causes osteoarthritis. In this paper, the outcomes are evaluated of arthroplasty applied because of ochronosis-related advanced stage osteoarthritis. The study included 6 joints of 3 cases in which ochronosis-related advanced stage osteoarthritis developed and arthroplasty was applied between 2000 and 2015. The cases were 2 males and 1 female with a mean age of 60.0±3.05 years. Osteoarthritis was observed in the knee joint in 2 cases and the hip joint in 1 case. Arthroplasty was applied to all the cases. In a mean follow-up period of 72 months no complications or recurrence were observed. Arthroplasty is an effective treatment method in advanced stage osteoarthritis which has developed as a result of ochronosis-related damage

Joint replacement associated with ochronosis in three cases, two were siblings