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Background . It is a common, yet unproven, belief that patients with post-inflammatory lung disease have a better functional reserve than patients with lung cancer when compared with their respective functional parameters of operability – forced expiratory volume in one second (FEV1), maximum oxygen uptake in litres per minute (VO2max) and the diffusion capacity for carbon monoxide (DLCO).  Objectives. The aim of this study was to compare a group of patients with lung cancer with a group with post-inflammatory lung disease according to their respective functional parameters of operability. We also aimed to investigate any associations of FEV 1 and/or DLCO with VO 2 max within the two groups.  Methods. We retrospectively included 100 adult patients considered for lung resection. All patients were worked up using a validated algorithm and were then sub-analysed according to their parameters of functional operability.  Results. Two-thirds of patients had post-inflammatory lung diseases whilst the rest had lung cancer. The majority of the patients in the lung cancer group had coexistent chronic obstructive pulmonary disease (COPD) ( n =18). Most ( n =47) of the patients in the post-inflammatory group were diagnosed with a form of pulmonary TB (active or previous). Among the two groups, the lung cancer group had a higher median %FEV 1 value (62.0%; interquartile range (IQR) 51.0 - 76.0) compared with the post-inflammatory group (52%; IQR 42.0 - 63.0; p =0.01). There was no difference for the %DLCO and %VO 2 max values. The lung cancer group also had higher predicted postoperative (ppo) values for %FEV 1 (41.0%; IQR 31.0 - 58.0 v. 34.0%; IQR 23.0 - 46.0; p =0.03, respectively) and %VO 2 max (58.0%; IQR 44.0 - 68.0 v. 46.0%; IQR 35.0 - 60.0; p =0.02). There was no difference in the %DLCO ppo values between the groups.  Conclusion. Patients with lung cancer had higher percentage values for FEV 1 and ppo parameters for %FEV 1 and %VO 2 max compared with those who had post-inflammatory lung disease. Our findings suggest that lung cancer patients have a better functional reserve

A comparison of the functional parameters of operability in patients with post-inflammatory lung disease and those with lung cancer requiring lung resection