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In the course of screening for new antibiotics active against methicillin-resistant Staphylococcus aureus, we isolated an antibacterial metabolite from the culture broth of a basidiomycete, which was named epicorazine C (1). Spectroscopic analysis revealed that 1 was a memberof the epidithiopiperazinedione group, represented by epicorazine A (2), B (3)^3) and 3822-A (4)4), which were isolated also from fermentations of the same culture (Fig. 1). In this case, it was the first isolation of epicorazines from a basidiomycete. Antibiotic 1 has already been

Epicorazine C, an Antimicrobial Metabolite from Stereum hirsutum HKI 0195.