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Novel 1beta-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.

Synthesis and Antibacterial Activity of Novel 1.BETA.-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position.