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converting enzyme (ICE) proteases, particularly caspase3, are activated during apoptosis, their overexpression inducing cell apoptosis is considered to play an important role in the initiation of apoptosis in variety of cell systems even though their molecular mechanisms are not well understood. During the course of our screening program for new antitumor antibiotics capable of inducing apoptosis in tumor cells, we isolated 6-hydroxytetrangulol6) as a caspase-3 inducer. Further investigation has resulted in the isolation of two novel substances belonging to the benzo [d] naphtho [1, 2-b] pyran-6-one group. We report herein the fermentation, isolation and structure determination of these two products designated FE35A (1) and FE35B (2). The producing organism of 1 and 2 identified as

New Ravidomycin Analogues, FE35A and FE35B, Apoptosis Inducers Produced by Streptomyces rochei.