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The isolation of two new antibiotics, PD 114,759 and PD 115,028, exhibiting in vivo antitumor activity at extremely low doses is described. The physico-chemical properties of these sulfur-containing compounds show that they represent a novel class of antitumor agents.

PD 114,759 and PD 115,028, novel antitumor antibiotics with phenomenal potency. I. Isolation and characterization.