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Objectives : This study was performed in order to evaluate the effects of S alviae Miltiorrhizae Radix (SMR) water extract against the cerebral hemorrhage and the blood-bra in barrier (BBB) impairment in the intracerebral hemorrhage (ICH).Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. SMR was orally given three times every 20 hours during 3 days after the ICH induction. Hematoma volume, water content of brain tissue and volume of evans blue leakage were examined. Myeloperoxidase (MPO) positive neutrophils and tumor necrosis f actor-α (TNF-α) were observed with immunofluorescence labeling and confocal microscope. Results : SMR significantly reduced the hematoma volume of the ICH-induced rat brain. SMR significantly reduced the water content of brain tissue of the ICH-induced rat brain. SMR reduced the percentage of the evans blue leakage around the hematoma on the caudate putamen c ompared to the ICH group, especially on the cerebral cortex. SMR significantly reduced the volume of the evans blue leakage level in the peri-hematoma regions of the ICH-induced rat brain. SMR significantly reduced MPO positive neutrophils in the peri-hematoma regions of the ICH-induced rat brain. SMR reduced the TNF-α expression in peri-hematoma regions of the ICH-induced rat brain. TNF-α immuno-labeled cells were coincide d with MPO immuno-labeled neutrophils in peri-hematoma regions of the ICH-induced rat brain.Conclusion : These results suggest that SMR plays a protective role against the blood-brain barrier impairment in the ICH through suppression of inflammation in the rat brain tissues.Key words : Salviae Miltiorrhizae Radix (SMR), BBB, Evans blue, MPO, TNF-α

Effects of Salviae Miltiorrhizae Radix on Blood-Brain Barrier Impairment of ICH-Induced Rats