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Objectives : This study was carried out to evaluate the acute oral toxicity of Dictamnus dasycarpus Turcz in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Dictamnus dasycarpus Turcz water extract of 1,000 ㎎/㎏(low dosage group), 2,000 ㎎/㎏(middle dosage group) and 4,000 ㎎/㎏(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in he matology. But we found out subtle changes in body weight and individual organ weight of the female group. In addition specific changes were observed in serum biochemical value of female group. Conclusions : These results suggest that water soluble extract of Dictamnus dasycarpus Turcz has not acute oral toxicity and oral LD50 value was over 4,000 ㎎/㎏ in SD rats. Also Dictamnus dasycarpus Turcz is expected to be sensitive with respect to the female.

Acute Oral Toxicity Study of Dictamnus dasycarpus Turcz in SD Rats