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Abstract: Denosumab, a monoclonal antibody against RANKL has superior efficacy against bone metastases. Its in vivo activity can be measured recently by dosing of serum C telopeptide, produced by collagen destruction by the osteoclast. We report the first patient series, across several tumor types of the efficacy of denosumab in normalising serum CTX.

Effective and Rapid Osteoclast Inhibition by Denosumab, is Reflected in Serum C Telopeptide (CTX), Across Different Tumor Types