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A 70-year-old woman, with an 8 cm tumor in the left kidney and multiple lung tumor and was diagnosed with Renal Cell Carcinoma (cT3aN0M1). The kidney tumor were unresectable and we started treatment with Tyrosine Kinase Inhibitors (sunitinib, pazopanib, axitinib, temsirolimus), but they failed because of disease progression or adverse events. We used nivolumab for 5 th line treatment; then, interstitial pneumonia was observed. The renal tumor shrunk and pulmonary metastatic foci revealed prominent disappearance. The renal tumor became resectable and we tried nephrectomy. Pathological findings were clear cell carcinoma with marked necrosis, hyperplasia and internal bleeding.

A CASE OF RENAL CELL CARCINOMA THAT ONCE NIVOLUMAB HAD BEEN EFFECTIVE IN METASTATIC LESION AND MADE PRIMARY TUMOR RESECTABLE